Title

Outcomes of Simultaneous Pancreas/Kidney Transplantation in BMI Extremes

Document Type

Conference Proceeding

Publication Date

2019

Publication Title

Am J Transplant

Abstract

Purpose: To assess the outcomes of simultaneous pancreas/kidney (SPK) transplantation in high and low BMI patients. Methods: A retrospective analysis of the United Network for Organ Sharing (UNOS) database was performed to identify SPK transplants between 1995 and 2018. Patients were divided according to preoperative BMI (<20, 20-35, and >35 kg/irf). Results: During the study period, 1628 patients with a BMI <20, 19505 with a BMI 20-35 and 269 with a BMI >35 underwent SPK transplantation. Their mean age was 37. 6∗3. 1, 40. 6±8. 5, and 42. 9±8. 1 years, respectively. The rate of delayed kidney graft function was higher in the BMI >35 group (7. 1, 7. 8, and 13. 7%, respectively p<0. 001). However, the rates of surgical site infection, anastomotic leak, and postoperative pancreatitis were similar between the groups. The 1-, 3-, and 5-year kidney graft survival rates were significantly higher in the BMI 20-35 group (1-year: 91. 1, 99. 2, and 86. 2%; 3-year: 76. 8, 84. 0, and71. 0%; 5-year: 62. 5, 69. 2, and56. 1%. respectively; p<0. 001). BMI did not significantly affect 1-and 3-year pancreatic graft survival; however, decreased 5-year survival was demonstrated in patient with BMI >35 (78. 3, 64. 7, and 46. 9%, respectively, p=0. 02). Conclusions: Although patient BMI does not affect post-SLK complication rates. long-term graft survival outcomes seem to be best in patients with a BMI 20-35! Preoperative weight optimization should be considered in this patient group.

Volume

19

First Page

1133

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