Mortality among patients with chronic hepatitis B (CHB) infection: the chronic hepatitis cohort study (CHeCS).

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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America


Background: According to death certificates, approximately 1800 persons die from hepatitis B annually in the United States (US); however, this figure may underestimate the true mortality from chronic hepatitis B (CHB).

Methods: We analyzed data from CHB patients seen in the Chronic Hepatitis Cohort Study (CHeCS) between January 1, 2006 and December 31, 2013. We compared overall and cause-specific death rates and mean age at death between CHeCS CHB decedents and US decedents from the multiple cause of death (MCOD) file.

Results: A total of 4389 CHB patients were followed for a mean of 5.38 years through December 31, 2014; 492 (11%) CHB patients died after a mean follow-up of 3.00 years. Compared to survivors, decedents were older, more likely to be White (40.6%), African-American (27.1%) or male (74.2%), and more likely to have cirrhosis (59.8%), diabetes (27.2%), alcohol abuse (17.7%), hepatocellular carcinoma (17.5%) or liver transplant (5.7%); whereas survivors were more likely to be Asian (48.8%) (all, p

Conclusions: Compared to the general population, CHB patients die at a younger age and at higher rates from all causes and liver-related causes. Death certificates underrepresent the true mortality from CHB.

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ePub ahead of print