Title

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers.

Document Type

Article

Publication Date

4-1-2017

Publication Title

Experimental dermatology

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, miRNAs, particularly, circulating miRNAs may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific miRNAs may be used to develop new therapeutic methods for psoriasis.

Medical Subject Headings

Biomarkers; Cell Proliferation; Humans; Immunity, Cellular; Keratinocytes; MicroRNAs; Molecular Targeted Therapy; Psoriasis; Severity of Illness Index

PubMed ID

27783430

Volume

26

Issue

4

First Page

359

Last Page

367

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