Title

New insights into microRNAs in skin wound healing.

Document Type

Article

Publication Date

12-1-2015

Publication Title

IUBMB life

Abstract

Chronic wounds are a major burden to overall healthcare cost and patient morbidity. Chronic wounds affect a large portion of the US, and billions of healthcare dollars are spent in their treatment and management. microRNAs (miRNAs) are small, noncoding double-stranded RNAs that post-transcriptionally downregulate the expression of protein-coding genes. Studies have identified miRNAs involved in all three phases of wound healing including inflammation, proliferation, and remodeling. Some miRNAs have been demonstrated in vitro with primary keratinocyte wound healing model and in vivo with mouse wound healing model through regulation of miRNA expression to affect the wound healing process. This review updates the current miRNAs involved in wound healing and discusses the future therapeutic implications and research directions.

Medical Subject Headings

Animals; Cell Proliferation; Dermatitis; Disease Models, Animal; Humans; Keratinocytes; Mice; MicroRNAs; Skin; Skin Physiological Phenomena; Wound Healing

PubMed ID

26596866

Volume

67

Issue

12

First Page

889

Last Page

896

Share

COinS