Recommended Citation
Fahs F, Bi X, Yu F, Zhou L, Mi Q. New insights into microRNAs in skin wound healing. IUBMB life 2015; 67(12):889-896.
Document Type
Article
Publication Date
12-1-2015
Publication Title
IUBMB life
Abstract
Chronic wounds are a major burden to overall healthcare cost and patient morbidity. Chronic wounds affect a large portion of the US, and billions of healthcare dollars are spent in their treatment and management. microRNAs (miRNAs) are small, noncoding double-stranded RNAs that post-transcriptionally downregulate the expression of protein-coding genes. Studies have identified miRNAs involved in all three phases of wound healing including inflammation, proliferation, and remodeling. Some miRNAs have been demonstrated in vitro with primary keratinocyte wound healing model and in vivo with mouse wound healing model through regulation of miRNA expression to affect the wound healing process. This review updates the current miRNAs involved in wound healing and discusses the future therapeutic implications and research directions.
Medical Subject Headings
Animals; Cell Proliferation; Dermatitis; Disease Models, Animal; Humans; Keratinocytes; Mice; MicroRNAs; Skin; Skin Physiological Phenomena; Wound Healing
PubMed ID
26596866
Volume
67
Issue
12
First Page
889
Last Page
896
