Title

Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies.

Document Type

Article

Publication Date

3-1-2014

Publication Title

Journal of drugs in dermatology : JDD

Abstract

BACKGROUND: Treatments for papulopustular rosacea (PPR) are limited.

OBJECTIVE: To demonstrate the efficacy and safety of once-daily ivermectin 1% cream in subjects with moderate to severe PPR.

METHODS: Two identically designed, randomized, double-blind, controlled studies of ivermectin 1% cream (IVM 1%) or vehicle once daily for 12 weeks were conducted in subjects with moderate to severe PPR. Efficacy assessments were Investigator's Global Assessment (IGA) of disease severity and inflammatory lesion counts. Safety assessments included incidence of adverse events (AEs) and local tolerance parameters. Subjects evaluated their rosacea and completed satisfaction and quality of life (QoL) questionnaires.

RESULTS: In both studies, a greater proportion of subjects in the IVM 1% group achieved treatment success (IGA "clear" or "almost clear"): 38.4% and 40.1% vs 11.6% and 18.8% for vehicle (both P

CONCLUSION: Ivermectin 1% cream was effective and safe in treating inflammatory lesions of papulopustular rosacea.

Medical Subject Headings

Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Dermatologic Agents; Double-Blind Method; Female; Humans; Ivermectin; Male; Middle Aged; Patient Satisfaction; Quality of Life; Rosacea; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Young Adult

PubMed ID

24595578

Volume

13

Issue

3

First Page

316

Last Page

323

Share

COinS