Proliferative nodule resembling angiomatoid Spitz tumor with degenerative atypia arising within a giant congenital nevus
Braunberger TL, Adelman M, Shwayder TA, Clarke LE, and Friedman BJ. Proliferative nodule resembling angiomatoid Spitz tumor with degenerative atypia arising within a giant congenital nevus. J Cutan Pathol 2020.
Journal of cutaneous pathology
Proliferative nodules arising within congenital melanocytic nevi (CMN) often present a diagnostic challenge given a close resemblance to melanoma. Several morphologic variants have been characterized. In difficult cases, ancillary molecular tests can be used to better exclude the possibility of malignant degeneration. Herein, we report a case of an unusual proliferative nodule with overlapping features of angiomatoid Spitz tumor and ancient melanocytic nevus, which demonstrated normal findings on both chromosomal microarray and a gene expression profiling assay.
ePub ahead of print