Adult-Onset Acquired Ichthyosis Revealing an Underlying Colon Adenocarcinoma

Document Type

Article

Publication Date

11-1-2024

Publication Title

Cureus

Abstract

Acquired ichthyosis is an uncommon dermatologic disorder that presents in adulthood and is often associated with systemic conditions, including malignancies. We report the case of a 38-year-old male patient who developed diffuse scaling characterized by rhomboidal, fish-like scales predominantly affecting the trunk and limb extensors, with sparing of the flexures, palms, and soles. Initial therapeutic interventions with emollients and corticosteroids were unsuccessful. A skin biopsy confirmed the diagnosis of acquired ichthyosis, and subsequent diagnostic imaging revealed an underlying colon adenocarcinoma. Notably, the patient's family history was significant for his mother's colon adenocarcinoma, suggesting a potential genetic predisposition. This case highlights the critical importance of conducting a comprehensive diagnostic evaluation for underlying malignancies upon the diagnosis of acquired ichthyosis, particularly in patients with pertinent familial cancer histories. Although the patient was lost to follow-up, this case underscores the role of acquired ichthyosis as a potential paraneoplastic marker, emphasizing the need for early detection and management of associated malignancies.

PubMed ID

39640179

Volume

16

Issue

11

First Page

73045

Last Page

73045

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