Title

Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock.

Document Type

Article

Publication Date

1-1-2016

Publication Title

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Abstract

OBJECTIVE: To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls.

RESULTS: F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assay's lowest detection range (78 ng/ml).

CONCLUSIONS: F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock.

Medical Subject Headings

Actins; Adult; Aged; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; ROC Curve; Shock, Septic; Systemic Inflammatory Response Syndrome; Thymosin

PubMed ID

26754286

Volume

21

Issue

2

First Page

180

Last Page

185

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