Immune Profile in the Immediate Aftermath of MVC and its Prediction of APNS

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Conference Proceeding

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Biological Psychiatry


Background: African Americans (AAs) experience an increased burden of motor vehicle collision (MVC) and rates of adverse posttraumatic neuropsychiatric sequelae (APNS) after MVC, versus non-Hispanic whites. Accumulating evidence suggests that immune cells play an important role in APNS development. Methods: AAs presenting to the Emergency Department (ED) within 24 hours of MVC were enrolled. ED assessment included measurement of pain symptoms (0-10 scale), severity of life threat (0-10 scale) and blood RNA sample (PAXgene) collection. Post-traumatic depressive (CES-D), stress (IES-R), and pain symptoms were assessed at six weeks, six months, and one year. Repeated measures linear regression analyses were performed evaluating whether circulating peritraumatic immune cell subtypes (i.e., neutrophils, monocytes, B-cells, CD4+ T-cells, estimated via application of CIBERSORT method to ED blood sample total RNA sequencing data) predicted APNS outcomes. False discovery rate threshold was set at 5%. Results: After adjustment for sociodemographic characteristics and perceived life threat within this study sample (n=183), the peritraumatic CD4+ T immune cell proportion predicted depressive (β = 19.5, p = 0.031), stress (β = 51.7, p = 0.008), and pain (β = 6.3, p = 0.002) symptom severity, and peritraumatic neutrophil proportion predicted pain (β = -2.9, p = 0.047). Conclusions: Among AAs experiencing MVC, an increased proportion of peritraumatic CD4+ T immune cells predicted more severe depressive, stress, and pain symptoms over time. Studies examining associations between peritraumatic immune phenotypes and APNS may provide pathogenic insights.


Supported By: NIAMS R01AR060852, UNC BIRCWH K12HD001441 Keywords: Psychoneuroimmunology, Posttraumatic Stress Symptoms, Depressive Symptoms, Motor Vehicle Collision, African Americans





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