530 Standardized evaluation of duration of loss of consciousness may aid in risk stratification for traumatic brain injury
Recommended Citation
Glotfelty J, Ji Y, Stritzel H, Huibregtse ME, House SL, Beaudoin FL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Jones CW, McLean SA. 530 Standardized evaluation of duration of loss of consciousness may aid in risk stratification for traumatic brain injury. Acad Emerg Med 2024; 31(S1):250.
Document Type
Conference Proceeding
Publication Date
5-13-2024
Publication Title
Acad Emerg Med
Abstract
Background and Objectives: Emergency physicians risk stratify millions of patients each year for traumatic brain injury (TBI). Patient report of loss of consciousness (LOC) is commonly used to identify individuals at increased TBI risk (e.g., for CT scanning). Many patients who report LOC report a relatively brief duration of LOC. Whether such reports of a relatively brief duration of LOC are associated with increased risk of TBI is not known. Methods: Trauma survivors (n?=?2721, mean age 35.1, 60.5% female, 75.3% MVC) presenting to 28 US emergency departments (EDs) were enrolled into a large-scale longitudinal Study. Enrolled patients were evaluated for head strike and LOC and had plasma samples obtained in the ED. GFAP levels were analyzed using the Quanterix Simoa Discovery Platform. Associations between LOC duration (few seconds (fewsec), <1?min (<1?min), and ?1?min (?1?min)), GFAP levels, and patient characteristics were assessed. Results: Among individuals who reported hitting their head (1287/2496, 52%), 314/1200 (26%) reported LOC. Among individuals reporting LOC, 105/270 (39%) reported LOC for a fewsec, 41/270 (15%) reported LOC for <1?min, and 124/270 (46%) reported LOC ?1?min, respectively. Mean GFAP levels differed between these 3 groups: 220?pg/mL (fewsec), 643?pg/mL (<1?min), and 841?pg/mL ?1?min), F?=?7.857, p?
Volume
31
Issue
S1
First Page
250
