A Single High Sensitivity Cardiac Troponin I Measurement from Siemens Healthineers Can Be Used to Rule out Acute Myocardial Infarction at Low Risk in Patients Presenting to the Emergency Department

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Conference Proceeding

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Clin Chem


Background: High sensitivity cardiac troponin (hs-cTn) assays are able to quantitate low concentrations of cTn and provide an opportunity to rule out acute myocardial infarction (MI) at an early stage following a patient's presentation to an emergency department. The objectives of the current study were to examine the performance of single hs-cTnI measurement strategy to rule out acute MI and predict 30-day safety outcomes at presentation in these patients. Methods: This was a prospective, observational study of patients (n = 2333). Acute MI occurred in 299 patients (12.8%). Patients presented to US emergency departments with suspected acute coronary syndrome. Cardiac troponin measurements were obtained using the investigational ADVIA Centaur XPT TNIH (hs-cTnI) Assay (Siemens Healthcare Diagnostics Inc.). Clinical data and hs-cTnI results were analyzed to determine: 1) clinical sensitivity and negative predictive value (NPV) for ruling out acute MI and 2) safety outcomes of acute MI and death at 30 days, using the hs-cTnI limit of detection (LoD) 1.6 ng/L concentration. Results: In patients with a hs-cTnI



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