A Single High Sensitivity Cardiac Troponin I Measurement from Siemens Healthineers Can Be Used to Rule out Acute Myocardial Infarction at Low Risk in Patients Presenting to the Emergency Department
Apple FS, Christenson R, DeFilippi C, McCord J, Sexter A, and Nowak R. A single high sensitivity cardiac troponin I measurement from siemens healthineers can be used to rule out acute myocardial infarction at low risk in patients presenting to the emergency department. Clin Chem 2018; 64:S37-S38.
Background: High sensitivity cardiac troponin (hs-cTn) assays are able to quantitate low concentrations of cTn and provide an opportunity to rule out acute myocardial infarction (MI) at an early stage following a patient's presentation to an emergency department. The objectives of the current study were to examine the performance of single hs-cTnI measurement strategy to rule out acute MI and predict 30-day safety outcomes at presentation in these patients. Methods: This was a prospective, observational study of patients (n = 2333). Acute MI occurred in 299 patients (12.8%). Patients presented to US emergency departments with suspected acute coronary syndrome. Cardiac troponin measurements were obtained using the investigational ADVIA Centaur XPT TNIH (hs-cTnI) Assay (Siemens Healthcare Diagnostics Inc.). Clinical data and hs-cTnI results were analyzed to determine: 1) clinical sensitivity and negative predictive value (NPV) for ruling out acute MI and 2) safety outcomes of acute MI and death at 30 days, using the hs-cTnI limit of detection (LoD) 1.6 ng/L concentration. Results: In patients with a hs-cTnI