Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study.
Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Janos B, and Ruff VA. Differential effects of teriparatide and denosumab on intact PTH and bone formation indices: AVA osteoporosis study. J Clin Endocrinol Metab 2016; 101(4):1353-63.
The Journal of clinical endocrinology and metabolism
We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab.
Medical Subject Headings
Aged; Aged, 80 and over; Anabolic Agents; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Middle Aged; Osteogenesis; Osteoporosis, Postmenopausal; Parathyroid Hormone; Teriparatide