The Utility of 24-hour Urine Calcium Excretion in Evaluating Kidney Stone (KS) Risk in Patients with Primary Hyperparathyroidism (PHPT)

Document Type

Conference Proceeding

Publication Date

9-27-2024

Publication Title

J Bone Miner Res

Abstract

There is currently a debate about the link between 24-hour urine calcium levels (24h-UCa) and the risk of kidney stone formation in patients with primary hyperparathyroidism (PHPT). The aim of this study was to assess the usefulness of measuring 24h-UCa excretion in assessing risk of kidney stones in PHPT patients. Additionally, we explored the prevalence of kidney stones among different genders, races and 24h-UCa levels. Of the 343 PHPT patients aged 21 to 91 years, 72 had kidney stones. The cohort consisted of 117 Blacks (101 females and 16 males) and 226 Whites (170 females and 56 males). The biochemical measurements included serum calcium (SCa), ionized calcium (iCa), serum creatinine (SCr), parathyroid hormone (PTH), and 24h-UCa. Hypercalciuria was defined by two criteria based 24-Uca: >400mg/day without regard to gender or >300 mg/day for men and >250 mg/day for women. Among the 343 PHPT patients, individuals without kidney stones were significantly older than those with kidney stones (Table 1). However, no significant differences were observed in biochemical variables between the groups with and without kidney stones. In both groups, the PTH levels were higher than the normal reference range, while the other variables were within the reference range (Table 1). The ANCOVA analysis revealed that 24h-UCa levels were significantly higher in men compared to women, and in Whites compared to Blacks, but not different between the patients with and without kidney stones. According to the Chi-Squared test results presented in Table 2, the prevalence of kidney stones was higher in Whites than in Blacks, and in men than in women. However, 24h-UCa levels did not significantly impact kidney stone prevalence (Table 2). In conclusion, the results suggest that although 24h-UCa levels may differ among genders and races, they might not be a crucial factor for evaluating kidney stones in patients with PHPT. These results suggest that the differences in kidney stone prevalence among genders and races are likely independent of the levels of 24h-UCa. More studies are necessary to validate these outcomes and investigate other possible risk factors for kidney stones in PHPT patients.

Volume

39

First Page

81

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