Henry Ford Health System
Please enter a search term
Home About Contact
Detroit Stroke Conference Henry Ford Hospital Osteoporosis and Bone & Mineral Disorders Symposium In Memoriam: Jerry Yee, M.D. Medical Education Research Forum Nursing Research Conference Surgery and Anesthesia Research Celebration Day
  1. Home
  2. In Memoriam: Jerry Yee, M.D.
  3. Articles
  4. Risk of bleeding and restenosis among chronic kidney disease patients undergoing percutaneous coronary intervention

Risk of bleeding and restenosis among chronic kidney disease patients undergoing percutaneous coronary intervention

N. Attallah
L. Yassine
K. Fisher
Jerry Yee

01-01-2005

Background: Bleeding risk is increased in renal failure due to impaired platelet adhesiveness. Patients who undergo percutaneous coronary intervention (PCI) are given multiple antiplatelet agents that..

more »

Background: Bleeding risk is increased in renal failure due to impaired platelet adhesiveness. Patients who undergo percutaneous coronary intervention (PCI) are given multiple antiplatelet agents that increase that risk. We retrospectively tested the hypothesis that chronic kidney disease (CKD) patients who undergo PCI are at higher risk of bleeding and restenosis (due to chronic inflammation) compared to patients with normal renal function. Methods: Patients who had PCI for non-ST elevation myocardial infarction or unstable angina between July 2001 and June 2003 (1,184 patients) were included in the study. All the patients were given periprocedural clopidogrel, aspirin and glycoprotein IIb/IIIa inhibitor if indicated, and then continued on clopidogrel and aspirin daily for 12 months. The patients were classified into 5 groups according to the CKD stage and followed-up for 12 months for development of major or minor bleeding, restenosis, length of hospital stay and survival. Results: The incidence of major bleeding within the first month (3.4% in normal kidney function patients (Gp1), 4.8% for CKD Stages 1 and 2 patients (Gp2), 5.2% for CKD Stage 3 patients (Gp3), 6.1% for CKD Stage 4 patients (Gp4) and 9.3% for CKD Stage 5 patients (Gp5), p = 0.001) and for minor bleeding (5.7% in Gp1, 6.5% for Gp2, 7.4% for Gp3, 9.2% for Gp4 and 11.3% for Gp5, p = 0.001) and the incidence of restenosis at one month (4.6% in Gp1, 5.3% for Gp2, 6.8% for Gp3, 7.3% for Gp4 and 9.6% for Gp5, p = 0.001) and 6 months (11.2% in Gp1, 13.5% for Gp2, 15.7% for Gp3, 16.4% for Gp4 and 19.7% for Gp5, p = 0.001) were higher with worsening CKD. Survival at one year was worse with worsening of the kidney function. Conclusion: Worsening of CKD is associated with progressively increased risk of minor and major bleeding, restenosis and death during and after PCI. ©2005 Dustri-Verlag Dr. K. Feistle.

« less

Article

https://scholarlycommons.henryford.com/context/nephrology_articles/article/1275/viewcontent

http://scholarlycommons.henryford.com/nephrology_articles/275

16370153

http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:16370153

Clinical Nephrology

64

http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:16370153

Henry Ford Health

Previous Item
Next Item
  • Home
  • About
  • Contact
  • Privacy policy