Title

Management of Acute Hepatotoxicity Including Medical Agents and Liver Support Systems.

Document Type

Article

Publication Date

2-1-2017

Publication Title

Clinics in liver disease

Abstract

Drug-induced liver injury (DILI) can be predictable or idiosyncratic and has an estimated incidence of approximately 20 cases per 100,000 persons per year. DILI is a common cause of acute liver failure in the United States. No accurate tests for diagnosing DILI exist, and its diagnosis is based on exclusion of other conditions. Managing DILI includes discontinuing the suspected causative agent and in selected cases administering an antidote. Liver support systems are used for long-term support or as a bridge to transplantation and are effective for improving encephalopathy, hyperbilirubinemia, and other liver-related conditions, but whether they improve survival remains uncertain.

Medical Subject Headings

Antidotes; Chemical and Drug Induced Liver Injury; Disease Progression; Female; Hemofiltration; Humans; Liver Failure, Acute; Liver, Artificial; Male; Prognosis; Risk Assessment; Severity of Illness Index; Survival Analysis; Treatment Outcome; Withholding Treatment

PubMed ID

27842770

Volume

21

Issue

1

First Page

163

Last Page

180

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