Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids
Recommended Citation
Desai R, Huang L, Gonzalez RS, and Muthuswamy SK. Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids. Mol Cancer Res 2024; 22(5):440-451.
Document Type
Article
Publication Date
5-2-2024
Publication Title
Molecular cancer research
Abstract
The study identifies an opportunity to discover a PKA-independent pathway downstream of oncogene GNAS for managing IPMN lesions and their progression to PDAC.
Medical Subject Headings
Humans; GTP-Binding Protein alpha Subunits, Gs; Cell Proliferation; Organoids; Chromogranins; Cyclic AMP-Dependent Protein Kinases; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal; Pancreatic Ducts; Acinar Cells
PubMed ID
38319286
Volume
22
Issue
5
First Page
440
Last Page
451
COinS
