Classically, Howship's lacunae and osteoid seams or tissue have been used for microscopic identification of sites of bone osteoclastic and osteoblastic cell activity respectively. Recent transmitted light and blue light fluorescence microscopic study of fresh, undemineralized, specially stained and tetracycline labeled bone specimens have supported this use of these parameters of bone resorption and formation. Reports that the osteoclast is not required for bone resorption are evaluated here; it is concluded that no evidence exsists for resorption of bone tissue without osteoclasts. This does not apply to the perilacunar phenomena observed in certain well-defined situations.
Epker, Bruce N. and Frost, Harold M.
"The Nature of Bone Resorption and Formation in Normalcy and Disease,"
Henry Ford Hospital Medical Journal
: Vol. 16
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol16/iss1/4