Tetracycline-based quantitative histological analysis was made of a rib biopsy taken from a girl afflicted with hyperphosphatasia. The study revealed essentially normal bone dynamics on trabeculae, but greatly increased turnover in the compacta, which was largely composed of woven bone. Since both bone resorption and lamellar bone formation could be unequivocally demonstrated on periosteal, Haversian, and cortical-endosteal surfaces, it is suggested that the direct cause of the cell behavioral abnormality responsible for this disease may arise locally within the bone, but external to the bone cells. Because of its familial nature, however, the ultimate cause probably represents an inborn intracellular defect.
Jett, S. and Frost, H. M.
"Tetracycline-Based Measurements of The Bone Dynamics in the Rib of A Girl with Hyperphosphatasia,"
Henry Ford Hospital Medical Journal
: Vol. 16
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol16/iss4/8