A method has been developed in vitro for quantitation of aortic valvular insufficiency (Al) based on the use of ladioactive traceis lo genei-ate graphic recordings of the movement of blood out of the ventricle and back again. The regurgitant fraction of stroke volume (peirent of Al) is read from this recording. The method was evaluated in a mechanical heart model by comparing Al values read from the istope recordings and Al values determined volumetrically. The recordings gave excellent agreement with the volumetric results (Corr. Coeff. .9). These in vitro results are of such quality that clinical trials seem justified.
Hildner, Frank J.; Pierson, William R.; Weinstock, Bernard; Drake, Ellet H.; and Ormond, Robert S.
"Quantitation of Aortic Valvular Insufficiency Using Radioactive Tracers: An Experimental Study In Vitro,"
Henry Ford Hospital Medical Journal
: Vol. 18
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol18/iss1/5