The diseases responsible for extremely high serum alkaline phosphatase aclivily in 45 patients were proliferative bone disease (10 patients) and hepato-biliary tract disease (35 patients). Conditions found in these patients that are not usually thought to cause such high phosphatase levels were: drug-induced cholestasis (6 patients), non-malignant extra-hepatic bile duct obstruction (3 patients), biliary or portal cirrhosis (5 patients), and primary hyperparathyroidism with generalized osteitis fibrosa (1 patient).
Patton, Roy B.
"Spectacular Elevations of Serum Alkaline Phosphatase: Clinical and Pathological Correlation Roy B.,"
Henry Ford Hospital Medical Journal
: Vol. 18
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol18/iss3/10