In 98 patients with primary hyperparathyroidism, 15 had objective evidence of duodenal ulcer disease. Following operative correction of the hyperparathyroidism, improvement of duodenal ulcer disease occurred usually, but not uniformly, if unassociated with non-beta islet cell tumors. Correction of hyperparathyroidism in patients with the Zollinger-Ellison syndrome does not significantly influence the peptic ulcer which should be given primary aggressive surgical treatment.
Block, Melvin A.; Frame, Boy; and Fox, Thomas A. Jr.
"The Clinical Course of Duodenal Ulcer Associated with Hyperparathyroidism,"
Henry Ford Hospital Medical Journal
: Vol. 19
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol19/iss1/4