In an experimental study of gastrocolic and duodenocolic fistulas, it was clearly seen in 10 animals that duodenocolic fistulas result in the most serious loss of nutrition. Death from starvation occurred in all 42 animals in 30 days. Gastrocolic fistulas similarly resulted in weight loss and death of the animals in an average of 42 days. Lengthy fistulas between the stomach and colon caused no obvious disturbances in the physiology of the gastrointestinal tract. The significant microscopic changes included destruction of the mucous membrane and a decrease in size of the villi. The other noteworthy observation was that fistulous aggregations of lymphoid cells In the upper Intestine may present the gross appearance of an ulcer.
Ponka, Joseph L.; Shaalan, A. Karim; and Pesaros, P. C.
"Gastrocolic and Duodenocolic Fistulas: An Experimental Study,"
Henry Ford Hospital Medical Journal
: Vol. 19
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol19/iss2/4