Serum C-reactive protein (CRP) levels in 351 patients with certain chronic diseases were assayed by a micro-double immunodiffusion technique developed and used in this hospital. Elevation of CRP values and severity of disease were evident in the following clinical entities: 31 of 54 patients (57%) with liver cirrhosis; 122 of 204 (60%) hepatitis patients; 34 of 52 (65%) patients with gastro-intestinal surgery; 8 of 21 (38%) uremic patients; and all of 20 patients with renal transplantation. There was good correlation between markedly elevated serum CRP values and degree of inflammation and/or physiologic stress during clinical course and recovery.
Hayashi, Hajime and LoGrippo, Gerald A.
"C-Reactive Protein: Potential Significance of Quantitation in Patients with Chronic Diseases,"
Henry Ford Hospital Medical Journal
: Vol. 20
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol20/iss2/7