Fifty-two cases with histologically proven carcinoma of the thyroid were studied. With some variation as to the expected incidence of the several cell types of tumor, possibly due to the small size of this series, the distribution of these cases encompassed all histologic types. Fifty-three (53%) percent of the cases where pre-operative I131 scans were recorded showed a positive, or "cold" scan. Fifty-five (55%) percent of all lesions showed extension of disease beyond the confines of the thyroid gland. This experience indicates that, although thyroid scintiscans provide useful information to be correlated with other data, there are distinct limitations to the study.
Evans, Douglas M.
"The Relationship of the Cold Nodule to Carcinoma of the Thyroid,"
Henry Ford Hospital Medical Journal
: Vol. 22
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol22/iss3/3