Using Frost's method for undecalcified bone sections, long bones of the lower extremities of ten rhesus monkeys were examined following two months' immobilization and compared with thirteen controls. A decrease in appositional rate and in the surface extent of the ossification process were noted in the immobilized animals. No typical change in resorption was noted. The immobilized animals showed a decreased cortical-total area ratio. These findings suggest that a decrease in activity affects bone by depressing functions mediated by the osteoblast without necessarily evoking an Increased remodelling response.
Schock, Charles C.; Noyes, Frank R.; Crouch, Michael M.; and Mathews, Catharina H. E.
"The Effects of Immobility on Long Bone Remodelling in the Rhesus Monkey,"
Henry Ford Hospital Medical Journal
: Vol. 23
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol23/iss3/2