Henry Ford Hospital Medical Journal


From a study of 38 patients, it may be concluded that, first, changes in serum testosterone levels of patients undergoing orchiectomy for metastatic carcinoma of the prostate are unrelated to the clinical course of the patient; second, no clear correlation exists between quantitative Leydig cell counts and levels of plasma testosterone; and, third, exacerbation of metastatic disease is observed while plasma testosterone remains in the castrate range. These observations question the exact function of the Leydig cell and its role in androgen production, and indicate that prostatic neoplasms have varying degrees of response to reduced androgen levels and/or androgen-Iike substances following castration.