This study analyzes the effect of temperature, perfusate composition, pH, and variable manufacturing lots in prolonging kidney allograft survival with Concanavalin A (Con A). Cold temperature (4°C), crystalloid composition of the perfusates, and neutral or mildly alkaline pH were important factors in the effect of Con A on prolonging allograft survival. Also, different lots of Con A from the same manufacturer produced variable results in prolonging survival. Thus, multiple factors should be considered if Con A is to be used to prolong kidney allograft survival.
Toledo-Pereyra, Luis H. and Simmons, Richard L.
"Prolonging Kidney Graft Survival with Concanavalin A: Effects of temperature, perfusate composition, pH, and different manufacturing lots,"
Henry Ford Hospital Medical Journal
: Vol. 26
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol26/iss3/10