Henry Ford Hospital Medical Journal


This paper describes the results of experiments designed to test the effectiveness of a new colloid hyperosmolar solution (Toledo-Pereyra) for renal hypothermic storage. Three experimental conditions were employed: 60 minutes of warm ischemia (37 C), 24 hours of hypothermic storage, and a combination of warm ischemia and hypothermic storage. Canine kidneys tolerated either one of the first two procedures when flushed with the colloid hyperosmolar solution before storage or transplantation. If warm ischemia was applied before 24 hours of hypothermic storage, four of six dogs survived more than 20 days after transplantation, while the other two died of uremia. Thus, this new solution offers a good medium for 24-hour hypothermic storage, as well as some protection from the adverse effects of warm ischemia.