Thirty-two patients with Paget's bone disease have been treated with the bisphosphonate APD. Nineteen had previously received treatment for Paget's disease with EHDP alone or in combination with calcitonin; 13 had not previously received treatment for Paget's disease. APD was given in a mean dose of 6.8 mg/kg of body weight during a period of 6 to 12 months. Bone pain disappeared or diminished in 91% of the patients. A very significant diminution of the biochemical indices of bone turnover was observed in all patients, but the response occurred faster in patients who had not previously received treatment for Paget's disease. In 10 patients, APD therapy was discontinued after biochemical remission of the Paget's disease had been achieved. In most patients, clear signs of reactivation of the disease appeared 9 to 10 months after APD therapy was discontinued.
Mautalen, Carlos A.
"Treatment of Paget's Bone Disease with the Bisphosphonate APD,"
Henry Ford Hospital Medical Journal
: Vol. 31
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol31/iss4/21