Henry Ford Hospital Medical Journal


The Acquired Immunodeficiency Syndrome (AIDS) first recognized in 1981, has been extensively studied, and the most recent studies have demonstrated that its defects extend well beyond the apparent deficient cell-mediated immunity to include humoral immunity, autoimmunity, and abnormal immunoregulation. The recent discovery of a retrovirus, HTLV III, as a possible etiologic agent is discussed in relation to other viruses known to cause immunodeficiency. Simian AIDS, an animal model of virus-induced immunodeficiency, is also discussed. Recommendations are made regarding the interpretation and limitations of immune testing in AIDS, including a discussion of how apparently healthy homosexuals and groups at risk develop an immunologic profile which mimics that of patients with AIDS.