In this retrospective study of 68 cases of medullary thyroid carcinoma (MTC), morphological features were studied, which could be helpful in prognosis and in the distinction between hereditary and sporadic forms of the disease. Necrosis within the tumors seemed to carry a poor prognosis. Bilateral MTC. unquestionable C-cell hyperplasia, glandular or follicular pattern, and thyroglobulin-positive cells seemed to be more prevalent in hereditary forms of the disease. A smaller proportion of calcitonin-immunoreactive cells were encountered in hereditary tumors than in sporadic tumors.
Franc, B.; Caillou, B.; Carrier, A. M.; Dutrieux-Berger, N.; Floquet, J.; Houcke, M.; Justrabo, E.; Lange, F.; Pages, A.; Rigaud, C.; Schwartz, A.; Viennet, M.; and Lebodic, M. F.
"Immunohistochemistry in Medullary Thyroid Carcinoma: Prognosis and Distinction Between Hereditary and Sporadic Tumors,"
Henry Ford Hospital Medical Journal
: Vol. 35
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol35/iss2/17