Henry Ford Hospital Medical Journal


A Northern Ireland/Australian family with multiple endocrine neoplasia type 2A is described. Three members of the first generation studied have died, two men (aged 35 and 51) as a result of metastatic medullary thyroid carcinoma and one woman (the index case, aged 50) due to hypertensive complications during thyroidectomy from an undiagnosed pheochromocytoma. All members of this family found by screening to have either medullary thyroid carcinoma or pheochromocytoma, or both, have been asymptomatic for their disease.