We assessed the lipid and apolipoprotein effects of hypocaloric dieting, increased physical activity, and dietary modification in severely overweight adults (body mass index [BMI] 43.05 kg/m-). The 34 women and four men enrolled in the ambulatory weight control program donated blood before, during, and after hypocaloric dieting (420 kcal/day). Mean values before dieting included cholesterol of 223 mg/dL, high-density lipoprotein (HDL) cholesterol of 43 mg/dL, and cholesterol/HDL cholesterol of 5.90. This placed our subjects at high risk for coronary artery disease. Other values included triglycerides of 138 mg/dL, apolipoprotein A-l of 152 mg/dL. and apolipoprotein B/apolipoprotein A-l of 0.64. Significant reductions during hypocaloric dieting included mean cholesterol of 171 mg/dL, triglycerides of 99 mg/dL. and apolipoprotein A-l of 120 mg/dL. During weight maintenance (mean BMI 36.08 kg/m²). significant reductions compared to baseline included a mean cholesterol of204 mg/dL and cholesterol/HDL cholesterol of 4.60. Also, a significant increase occurred in HDL cholesterol (51 mg/dL). but a nonsignificant elevation was observed in apolipoprotein A-l (180 mg/dL). In four subjects, discordant ratios of cholesterol/HDL cholesterol or apolipoprotein B/apolipoprotein A-1 were seen. and one ratio improved in two subjects despite relapse of obesity. Changes in both HDL composition and HDL particle concentration may explain elevations of HDL cholesterol and apolipoprotein A-l after dieting. Discordance between lipid and apolipoprotein ratios may occur. Improvement in lipids or apolipoproteins may be seen despite regained weight.
Fachnie, J. David and Foreback, Craig C.
"Effects of Weight Reduction, Exercise, and Diet Modification on Lipids and Apolipoproteins A-l and B in Severely Obese Persons,"
Henry Ford Hospital Medical Journal
: Vol. 35
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol35/iss4/12