We have studied seven subjects with medullary thyroid carcinoma. Each had elevated basal serum calcitonin (CT) levels following total thyroidectomy. After subcutaneous administration of 100 μg of SMS 201-995, blood samples were collected at 60-minute intervals for six hours. Two patients showed a marked decrease of CT levels (patient A: baseline 565 μg/mL, nadir 150 μg/mL; patient B: baseline 1,632 μg/mL, nadir 416 μg/mL). The other five patients showed no significant change in comparison with saline infusion. Two patients were treated with SMS 201-995 (300 μg/day)for 90 days. One of these patients responded to the acute SMS 201-995 test and had CT levels persistently 50% lower than pretreatment values during this 90-day period. The other patient, whose CT levels did not decrease during the acute test, had persistently high values during this 90-day period but had relief of watery diarrhea even after the therapeutic trial was discontinued.
Libroia, Alfonso; Verga, Uberta; Di Sacco, Gianleone; Piolini, Marco; and Muratori, Fabrizio
"Use of Somatostatin Analog SMS 201-995 in Medullary Thyroid Carcinoma,"
Henry Ford Hospital Medical Journal
: Vol. 37
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol37/iss3/19