MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke
Chen J, Cui C, Yang X, Xu J, Venkat P, Zacharek A, Yu P, Chopp M. Mir-126 affects brain-heart interaction after cerebral ischemic stroke. Transl Stroke Res. 2017;8(4):374-385.
Transl Stroke Res
Cardiovascular diseases are approximately three times higher in patients with neurological deficits than in patients without neurological deficits. MicroRNA-126 (MiR-126) facilitates vascular remodeling and decreases fibrosis and is emerging as an important factor in the pathogenesis of cardiovascular diseases and cerebral stroke. In this study, we tested the hypothesis that decreased miR-126 after ischemic stroke may play an important role in regulating cardiac function. Wild-type (WT), specific conditional-knockout endothelial cell miR-126 (miR-126
Medical Subject Headings
Actins; Animals; Animals, Newborn; Brain; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Heart Diseases; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Myocardium; Myocytes, Cardiac; NADPH Oxidase 2; Transforming Growth Factor beta; Vascular Cell Adhesion Molecule-1