Title

Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone.

Document Type

Article

Publication Date

12-1-2016

Publication Title

American journal of physiology. Renal physiology

Abstract

Connecting tubule glomerular feedback (CTGF) is a mechanism where an increase in sodium (Na) concentration in the connecting tubule (CNT) causes the afferent arteriole (Af-Art) to dilate. We recently reported that aldosterone within the CNT lumen enhances CTGF via a nongenomic effect involving GPR30 receptors and sodium/hydrogen exchanger (NHE), but the signaling pathways of this mechanism are unknown. We hypothesize that aldosterone enhances CTGF via cAMP/protein kinase A (PKA) pathway that activates protein kinase C (PKC) and stimulates superoxide (O

Medical Subject Headings

Aldosterone; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic N-Oxides; Dose-Response Relationship, Drug; Feedback, Physiological; Isoquinolines; Kidney Glomerulus; Male; Protein Kinase C; Rabbits; Signal Transduction; Sodium Chloride; Spin Labels; Sulfonamides

PubMed ID

27413197

Volume

311

Issue

6

First Page

1182

Last Page

1182

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