SODIUM RESTRICTION IN HEART FAILURE: A META-ANALYSIS OF CLINICAL OUTCOMES FROM RCTS TARGETING <2G INTAKE

Document Type

Conference Proceeding

Publication Date

4-2-2024

Publication Title

J Am Coll Cardiol

Abstract

Background Sodium restriction is recommended as part of heart failure (HF) management, yet its clinical efficacy remain controversial. Methods We sourced studies from multiple databases to included RCTs that examined the effects of <2 g sodium interventions compared with no restriction on clinical outcomes in patients with HF. Key outcomes assessed were all-cause mortality, all-cause hospitalization, cardiovascular hospitalization, and HF hospitalization. Inverse variance method with Paule-Mandel estimator for tau^2 and Hartung-Knapp adjustment for random effects model was used to pool outcomes. Results Eight RCTs were included. For all-cause mortality, sodium restriction exhibited a risk ratio (RR) of 1.10 (95% CI: 0.67-1.80) compared with no restriction, without significant heterogeneity (I^2 = 0%) [PANEL A]. For all-cause hospitalization, the RR for sodium restriction compared with no restriction was 0.93 (95% CI: 0.63-1.37) with no evident heterogeneity (I^2 = 0%) [PANEL B]. Regarding cardiovascular hospitalization, the RR for sodium restriction compared with no restriction was marked at 0.92 (95% CI: 0.03-26.45), presenting a modest heterogeneity (I^2 = 22%) [PANEL C]. Concerning HF hospitalization, sodium restriction compared with no restriction yielded an RR of 0.82 (95% CI: 0.16-4.34), accompanied by moderate heterogeneity (I^2 = 45%) [PANEL D]. Conclusion Our analysis underscores that < 2 g of sodium restriction in patients with HF yields nuanced outcomes. [Formula presented]

Volume

83

Issue

13

First Page

797

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