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Henry Ford Hospital
Background: Due to poor sensitivity, the FDA mandated that rapid influenza antigen (IAT) must be phased out by 2018. At our institution, an on-site rapid influenza PCR (PCR) was implemented in emergency departments (ED) at the start of the 2016-2017 influenza season. The purpose of this study was to examine the impact of influenza PCR testing on antimicrobial utilization in the ED. Methods: This multicenter quasiexperimental study included adults over the age of 50 who were tested for influenza, and discharged from the ED. Subjects were matched 2:1 by age, sex, month of testing, and ED site. The pre-implementation group had IAT (Jan-Apr 2016) and the post-implementation had PCR testing (Jan-Apr 2017). The primary outcome was antiviral utilization. Other outcomes included diagnostic yield, test turnaround time (TAT), receipt of antibiotics, and 30-day revisit.Results: The PCR group of 116 patients (pts) were matched to 232 pts in IAT group (Table 1). Positive results for influenza were reported in 37.9% of PCR versus 18.1% of IAT groups (p<0.001); TAT 0.95 (0.75-1.4) hours in PCR vs. 0.60 (0.40-0.85) hours in IAT group (P<0.001). Oseltamivir was initiated in the ED in 21% of PCR vs. 11% of IAT group (p<0.001). An additional 28% in PCR group received oseltamivir at ED discharge vs. 15% in IAT group (p=0.004). Antibiotics were administered in the ED to 8% in PCR group vs. 15% in the IAT group. A positive influenza test was associated with less antibiotic use OR 0.454 (95% CI 0.213-0.967), while abnormal chest radiograph (CXR) and WBC was associated with increased antibiotic use OR 3.667 (1.743-7.715). The 30-day revisit was 3.8% and 10.8% in the PCR vs. IAT groups respectively (p=0.034).Conclusion: Replacing IAT with PCR testing increased diagnostic yield for influenza and receipt of oseltamivir and decreased antibiotic utilization in the ED. Independent predictors for antibiotic use were abnormal CXR and WBC, while positive influenza testing was protective.
Williams, Jonathan; Mercuro, Nicholas J; Vahia, Amit; Rizvi, Hira; Hameed, Mujtaba; Bhargava, Pallavi; Abreu-Lanfranco, Odaliz; Samuel, Linoj; and Alangaden, George J., "Impact on Antimicrobial Utilization in the Emergency Department of a Point of Care Polymerase Chain Reaction Compared to Antigen Testing for Influenza" (2019). Clinical Research. 4.