Exosomes in stroke pathogenesis and therapy

Document Type

Article

Publication Date

4-1-2016

Publication Title

The Journal of clinical investigation

Abstract

Stroke is one of the leading causes of death and disability worldwide. Stroke recovery is orchestrated by a set of highly interactive processes that involve the neurovascular unit and neural stem cells. Emerging data suggest that exosomes play an important role in intercellular communication by transferring exosomal protein and RNA cargo between source and target cells in the brain. Here, we review these advances and their impact on promoting coupled brain remodeling processes after stroke. The use of exosomes for therapeutic applications in stroke is also highlighted.

Medical Subject Headings

Animals; Brain; Exosomes; Humans; Nerve Tissue Proteins; Neural Stem Cells; RNA; Stroke

PubMed ID

27035810

Volume

126

Issue

4

First Page

1190

Last Page

1197

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