Targeting Triple Negative Breast Cancer with a Small-sized Paramagnetic Nanoparticle
Zhang L, Varma NR, Gang ZZ, Ewing JR, Arbab AS, and Ali MM. Targeting triple negative breast cancer with a small-sized paramagnetic nanoparticle. J Nanomed Nanotechnol 2016; 7(5).
J Nanomed Nanotechnol
There is no available targeted therapy or imaging agent for triple negative breast cancer (TNBC). We developed a small-sized dendrimer-based nanoparticle containing a clinical relevant MRI contrast agent, GdDOTA and a NIR fluorescent dye, DL680. Systemic delivery of dual-modal nanoparticles led to accumulation of the agents in a flank mouse model of TNBC that were detected by both optical and MR imaging.