Targeting Triple Negative Breast Cancer with a Small-sized Paramagnetic Nanoparticle

Authors

Li Zhang, Henry Ford HealthFollow
Nadimpalli R. Varma, Henry Ford Health
Zhenggang Zhang, Henry Ford HealthFollow
James R. Ewing, Henry Ford HealthFollow
Ali Arbab
Meser M. Ali, Henry Ford HealthFollow

Recommended Citation

Zhang L, Varma NR, Gang ZZ, Ewing JR, Arbab AS, and Ali MM. Targeting triple negative breast cancer with a small-sized paramagnetic nanoparticle. J Nanomed Nanotechnol 2016; 7(5).

Document Type

Article

Publication Date

10-1-2016

Publication Title

J Nanomed Nanotechnol

Abstract

There is no available targeted therapy or imaging agent for triple negative breast cancer (TNBC). We developed a small-sized dendrimer-based nanoparticle containing a clinical relevant MRI contrast agent, GdDOTA and a NIR fluorescent dye, DL680. Systemic delivery of dual-modal nanoparticles led to accumulation of the agents in a flank mouse model of TNBC that were detected by both optical and MR imaging.

PubMed ID

28018751

Volume

7

Issue

5