Models and mechanisms of vascular dementia
Venkat P, Chopp M, and Chen J. Models and mechanisms of vascular dementia. Exp Neurol 2015; 272:97-108.
Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options.
Medical Subject Headings
Alzheimer Disease; Animals; Cognition Disorders; Dementia, Vascular; Disease Models, Animal; Disease Progression; Humans; Hypertension; Metabolic Diseases; Risk Factors