Role of the glymphatic system in ageing and diabetes mellitus impaired cognitive function
Recommended Citation
Zhang L, Chopp M, Jiang Q, and Zhang Z. Role of the glymphatic system in ageing and diabetes mellitus impaired cognitive function. Stroke Vasc Neurol 2019; Epub ahead of print.
Document Type
Article
Publication Date
2019
Publication Title
Stroke Vasc Neurol
Abstract
Diabetes mellitus (DM) is a common metabolic disease in the middle-aged and older population, and is associated with cognitive impairment and an increased risk of developing dementia. The glymphatic system is a recently characterised brain-wide cerebrospinal fluid and interstitial fluid drainage pathway that enables the clearance of interstitial metabolic waste from the brain parenchyma. Emerging data suggest that DM and ageing impair the glymphatic system, leading to accumulation of metabolic wastes including amyloid-β within the brain parenchyma, and consequently provoking cognitive dysfunction. In this review, we concisely discuss recent findings regarding the role of the glymphatic system in DM and ageing associated cognitive impairment.
PubMed ID
31338217
ePublication
ePub ahead of print
