Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex

Authors

Maria Medalla
Wayne Chang
Samantha M. Calderazzo
Veronica Go
Alexandra Tsolias
Joseph W. Goodliffe
Dhruba Pathak
Diego De Alba
Monica Pessina
Douglas L. Rosene
Benjamin Buller, Henry Ford HealthFollow
Tara L. Moore

Recommended Citation

Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, and Moore TL. Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci 2020; 40(17):3385-3407.

Document Type

Article

Publication Date

4-22-2020

Publication Title

The Journal of neuroscience

Abstract

Functional recovery after cortical injury, such as stroke, is associated with neural circuit reorganization, but the underlying mechanisms and efficacy of therapeutic interventions promoting neural plasticity in primates are not well understood. Bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which mediate cell-to-cell inflammatory and trophic signaling, are thought be viable therapeutic targets. We recently showed, in aged female rhesus monkeys, that systemic administration of MSC-EVs enhances recovery of function after injury of the primary motor cortex, likely through enhancing plasticity in perilesional motor and premotor cortices. Here, using

Comments

Pre-embargo full-text article available at: http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:32241837

PubMed ID

32241837

Volume

40

Issue

17

First Page

3385

Last Page

3407