Title

Functional Neuroanatomy of Secondary Self-Injurious Behavior.

Document Type

Article

Publication Date

1-1-2018

Publication Title

Pediatric neurosurgery

Abstract

BACKGROUND: Secondary self-injurious behavior (SSIB) is underreported and predominantly not associated with suicide. In both adults and children, SSIB can cause intractable self-harm and is associated with a variety of clinical disorders, particularly those involving dysfunctional motor control.

METHODS: We performed a literature review evaluating the clinical efficacy of deep-brain stimulation (DBS) as modulating SSIB observations and review current progress in preclinical SSIB animal studies.

RESULTS: Neuromodulation is an effective therapeutic option for several movement disorders. Interestingly, this approach is emerging as a potentially effective treatment for movement disorder-associated SSIB (secondary); however, it is important to understand the neuroanatomy, clinical appraisal, and outcome data when considering surgical therapy for SSIB.

CONCLUSION: The current review examines the literature encompassing animal models and human case studies while identifying existing hypotheses from cytoarchitectonic-based targeting to neurotransmitter-based pathways. This review also highlights the need for awareness of an underrecognized pathology that may be amenable to DBS.

Medical Subject Headings

Animals; Basal Ganglia; Brain; Deep Brain Stimulation; Humans; Mental Disorders; Movement Disorders; Neuroanatomy; Pediatrics; Self-Injurious Behavior

PubMed ID

29402877

Volume

53

Issue

2

First Page

71

Last Page

80

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