Interrelationship between depression, anxiety, pain, and treatment adherence in hemophilia: Results from a US cross-sectional survey
Witkop ML, Lambing A, Nichols CD, Munn JE, Anderson TL, and Tortella BJ. Interrelationship between depression, anxiety, pain, and treatment adherence in hemophilia: Results from a US cross-sectional survey. Patient Prefer Adherence 2019; 13:1577-1587.
Patient Prefer Adherence
Purpose: Depression, anxiety, pain, and treatment adherence have reciprocal effects not characterized extensively in hemophilia. This study explored the relationships between depression, anxiety, chronic pain, and treatment adherence in adults with hemophilia. Patients and methods: Adults with self-reported hemophilia A or B completed the crosssectional IMPACT QoL II survey. Depression (9-item Patient Health Questionnaire [PHQ-9]), anxiety (7-item Generalized Anxiety Disorder scale [GAD-7]), chronic pain (Faces Pain Scale- Revised [FPS-R]), social support (Duke UNC Functional Social Support questionnaire), level of pain control, clotting factor treatment adherence (VERITAS-Pro or -PRN), and previous depression/anxiety were analyzed. Results: Among 200 participants (male, 77.3%; female, 22.8%), 54% had PHQ-9 and 52% had GAD-7 scores indicating moderate to severe depression or anxiety without diagnosis of either disorder. Participants with PHQ-9 scores ≥10 (moderate to severe depression) were more likely to have lower treatment adherence than those with PHQ-9 scores <10 >(P