Title

Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.

Document Type

Article

Publication Date

6-15-2018

Publication Title

American journal of respiratory and critical care medicine

Abstract

RATIONALE: Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response.

OBJECTIVES: To identify genetic variants important for bronchodilator drug response (BDR) in racially diverse children.

METHODS: We performed the first whole-genome sequencing pharmacogenetics study from 1,441 children with asthma from the tails of the BDR distribution to identify genetic association with BDR.

MEASUREMENTS AND MAIN RESULTS: We identified population-specific and shared genetic variants associated with BDR, including genome-wide significant (P < 3.53 × 10

CONCLUSIONS: The lack of minority data, despite a collaboration of eight universities and 13 individual laboratories, highlights the urgent need for a dedicated national effort to prioritize diversity in research. Our study expands the understanding of pharmacogenetic analyses in racially/ethnically diverse populations and advances the foundation for precision medicine in at-risk and understudied minority populations.

Medical Subject Headings

Adolescent; African Americans; Albuterol; Asthma; Bronchodilator Agents; Child; Female; Genome-Wide Association Study; Hispanic Americans; Humans; Male; Mexican Americans; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Race Factors; United States

PubMed ID

29509491

Volume

197

Issue

12

First Page

1552

Last Page

1564

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