Association of Magnesium Status With Hepatic Fibrosis Differs by Race/Ethnicity in Adults: National Health and Nutrition Examination Survey (NHANES) 2017 to 2020

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Conference Proceeding

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Publication Title

Current Developments in Nutrition


Objectives: Magnesium plays an important role in multiple metabolic disorders including diabetes, and is linked with the liver function. There are disparities in hepatic fibrosis risk based on sex and race/ethnicity in the US population. However, very few studies have examined whether the association between magnesium intake and liver fibrosis is similar across different racial/ethnic groups or between women and men.

Methods: Utilizing data from the NHANES 2017 to March 2020, 6,972 participants aged 20 years and older who completed the transient elastography examination were analyzed. The median liver stiffness of 8.2 kPa was used to identify subjects with significant fibrosis (≥F2). Intakes of magnesium and calcium were determined from 24-hour dietary recalls and supplement interviews. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Interaction between magnesium intake and race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, other), and between magnesium intake and gender, were examined, followed by stratified analyses.

Results: The age-adjusted prevalence of significant fibrosis (≥F2) was 9.92% for non-Hispanic Whites, 9.02% for non-Hispanic Blacks, 10.52% for Hispanics, 6.57% for non-Hispanic Asians, and 19.15% for Others. After adjustment for confounders, total energy and calcium intake, a higher total magnesium intake was associated with decreased odds of significant fibrosis (OR: 0.89; 95% CI: 0.79, 1.00) comparing highest vs. lowest tertile (Ptrend = 0.04). Among non-Hispanic Blacks, total magnesium intake was associated with lower odds of significant fibrosis in males but not in females (p-interaction < 0.01). The inverse association between total magnesium intake and significant fibrosis was found in female non-Hispanic Whites (p-interaction = 0.09).

Conclusions: We found that higher magnesium intake was associated with reduced risk of significant fibrosis in adults, and this inverse association might be dependent on gender and race/ethnicity. Further studies are needed to confirm the findings.



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