Is Cord Blood IgE Associated with Allergic Sensitization, Total IgE, FeNO, Lung Function, and Atopic Diseases During Pre-Adolescence?
Recommended Citation
O’Reilly DT, Zoratti E, Eapen A, Kim H, Sitarik A, Joseph C, Ownby D, Todter E, Wegienka G, Cole Johnson C. Is Cord Blood IgE Associated with Allergic Sensitization, Total IgE, FeNO, Lung Function, and Atopic Diseases During Pre-Adolescence?. J Allergy Clin Immunol 2024; 153(2):AB175.
Document Type
Conference Proceeding
Publication Date
2-1-2024
Publication Title
J Allergy Clin Immunol
Abstract
Rationale: Atopic conditions are common and represent a substantial healthcare burden. Investigation of cord blood IgE as a predictor of future atopic disease has yielded varying results. We aimed to investigate these associations in a racially diverse population through our Wayne County Health, Environment and Allergy Longitudinal (WHEALS) population-based birth cohort. Methods: Of the 1258 original WHEALS participants, 839 were included in at least one analysis. The association between cord blood IgE and childhood characteristics of atopy and allergic disorders was evaluated. Ten-year atopic outcomes included allergen sensitization via skin prick test (SPT), serum allergen-specific IgE (sIgE), fractional exhaled nitric oxide (FeNO), spirometric measures, and diagnosis of current asthma, atopic dermatitis (AD), and allergic rhinitis. Total IgE was assessed at multiple timepoints to 10 years. Models were adjusted for several variables including race, maternal sensitization, maternal prenatal antibiotic use, maternal marital status, household income, and firstborn status of child. Results: Cord IgE was associated with higher serum total IgE at 6-month, 1-year, 2-year, and 10-year visits (p < 0.001). Significant associations were also observed with binary sIgE sensitization (p < 0.001), and sIgE multi-sensitization (p=0.012). No associations were apparent with SPT, FeNO, airway obstruction (FEV1/FVC) or diagnosis of current asthma, AD, or allergic rhinitis. Conclusions: Higher cord IgE was associated with higher future serum IgE and allergen sensitization at 10 years measured by serum sIgE testing. However, cord IgE did not predict sensitization measured by SPT, clinical atopic disease diagnosis or other common characteristics of atopy among a diverse cohort of children.
Volume
153
Issue
2
First Page
AB175
