In Situ Immunization Via Non-Surgical Ablation to Prevent Local and Distant Tumor Recurrence

Authors

Jesse J. Veenstra
Heather M. Gibson
Svend Freytag, Henry Ford HealthFollow
Peter J. Littrup
Wei-Zen Wei

Recommended Citation

Veenstra JJ, Gibson HM, Freytag S, Littrup PJ, and Wei WZ. immunization via non-surgical ablation to prevent local and distant tumor recurrence. Oncoimmunology 2015; 4(3):e989762.

Document Type

Article

Publication Date

3-1-2015

Publication Title

Oncoimmunology

Abstract

Host immunities are induced during cryoablation or oncolytic adenovirus therapy when the entire repertoire of tumor associated antigens (TAA) is released. Local and systemic protection is enhanced by the combined treatment with toll-like receptor agonist or immune stimulating cytokines. Non-surgical tumor ablation is an effective platform for in situ immunization.

PubMed ID

25949901

Volume

4

Issue

3

First Page

989762

Last Page

989762