In Situ Immunization Via Non-Surgical Ablation to Prevent Local and Distant Tumor Recurrence
Veenstra JJ, Gibson HM, Freytag S, Littrup PJ, and Wei WZ. immunization via non-surgical ablation to prevent local and distant tumor recurrence. Oncoimmunology 2015; 4(3):e989762.
Host immunities are induced during cryoablation or oncolytic adenovirus therapy when the entire repertoire of tumor associated antigens (TAA) is released. Local and systemic protection is enhanced by the combined treatment with toll-like receptor agonist or immune stimulating cytokines. Non-surgical tumor ablation is an effective platform for in situ immunization.