Quality of Life (QOL) of Patients with Human Papillomavirus (HPV)-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) in NRG-HN002
Recommended Citation
Truong MT, Torres-Saavedra P, Gillison M, Caudell JJ, Gibson MK, Waldron J, Xia P, Chung CH, Kong CS, Yao M, Jordan R, Subramaniam RM, Lewin JS, Geiger JL, Kang H, Blakaj DM, Mell LK, Harris J, Movsas B, Yom SS. Quality of Life (QOL) of Patients with Human Papillomavirus (HPV)-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) in NRG-HN002. Int J Radiat Oncol Biol Phys 2024; 120(2 Suppl):S121.
Document Type
Conference Proceeding
Publication Date
10-1-2024
Publication Title
Int J Radiat Oncol Biol Phys
Abstract
Purpose/Objective(s): To evaluate secondary QOL endpoints of patients with HPV-associated OPSCC receiving reduced-dose radiation. Materials/Methods: NRG-HN002 was a phase II randomized trial in patients with p16-positive OPSCC receiving 60 Gy of intensity-modulated radiation therapy and cisplatin (IMRTC) over 6 weeks or IMRT alone over 5 weeks. The MD Anderson Dysphagia Inventory (MDADI), Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), University of Washington Quality of Life Questionnaire, Version 4 (UW-QOL), and Work Status Questionnaire were collected at baseline, end of RT, 6, 12 and 24 months from end of RT. Multivariable linear mixed models were used to analyze MDADI and UW-QOL composite scores and mixed ordinal logistic models for PSS-HN and individual UW-QOL items (2-sided alpha = 0.05). Results: Completion rates were 86-93% at baseline (n = 306) and 69-73% at 2 years. Most domains exhibited deterioration at the end of RT and improved scores 6, 12, and 24 months post-RT. UW-QOL anxiety scores were lower at baseline and end of RT, then improved at 6-24 months. UW-QOL shoulder function was decreased up to 6 months post-RT. All domains showed a statistically significant score difference over time (p < 0.05). Except for PSS-HN public eating (P = 0.03), UW-QOL swallowing (P = 0.045), and mood (P = 0.02), the arms were not significantly different for any domain over time. PSS-HN public eating scores were worse for IMRT than IMRTC at 24 months post-RT (OR = 4.90, 95% CI = [1.43-16.76]). UW-QOL swallowing (OR = 0.45 [0.20-1.00]) and mood scores (OR = 0.27 [0.13-0.58]) were better for IMRT at the end of RT. UW-QOL activity (OR = 0.46 [0.27-0.78]) and recreation (OR = 0.49 [0.29-0.80]) scores were better for IMRT over time. At 6 months post-RT, patients working full-time for IMRTC and IMRT were 45.4% vs. 52.2% (P = 0.74). Conclusion: Reduced dose radiation impairs QOL and swallowing-related QOL at the end of RT, with recovery at 6 months and onwards. PSS-HN public eating was worse for IMRT at 24 months post-RT. UW-QOL swallowing and mood were better for IMRT at the end of RT, and activity and recreation were better for IMRT over time.
Volume
120
Issue
2 Suppl
First Page
S121
